Non-permissiveness of synovial membrane cells to human parvovirus B19 in vitro.
نویسندگان
چکیده
The ability of cultured human synovial cells derived from synovial membrane and cartilage to support the replication of human parvovirus B19 was assessed. No viral DNA synthesis nor viral antigens were detected suggesting that B19 virus is not capable of replicating in synovial cells. The significance of this finding in relationship to the pathogenesis of parvovirus arthritis is discussed.
منابع مشابه
Persistence of parvovirus B19 in synovial fluid and bone marrow.
OBJECTIVES To determine whether parvovirus B19 (B19) persists in rheumatoid arthritis (RA). METHODS Polymerase chain reaction (PCR) was used to detect parvovirus B19 genome in the synovial fluid cells or peripheral blood mononuclear cells from 61 patients with early RA; bone marrow from one patient was also studied. The synovium or synovial fluid cells from 28 patients with advanced RA, and s...
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ورودعنوان ژورنال:
- The Journal of general virology
دوره 73 ( Pt 6) شماره
صفحات -
تاریخ انتشار 1992